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Efffects of pain inducing agents on voltage dependent calcium currents in the trigeminal ganglion

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Authors
Park, Kyungpyo; Kim, Seong-Ah; Kim, Youn-Bae; Kim, Joong-Soo; Lee, Jong-Heun
Issue Date
2001-04
Publisher
The Korean Academy of Oral Biology
Citation
International Journal of Oral Biology 26:1-6, 2001.
Keywords
trigeminal ganglion(TG)voltage dependent Ca^2+ current(I_Ca)bradykininhistamineeugenol
Abstract
Trigeminal ganglion (TG) neurons are primary sensory neurons involved in the transmission of orofacial sensation, including pain. It is known that intracellular free calcium concentration plays a critical role in neurotransmitter release. In the present study, we examined the effects of pain-inducing agents, bradykinin and histamine, on voltage dependent Ca^2+ current (I_Ca) and compared these with the effects of the analgesic agent, eugenol. I_Ca was measured using a whole-cell patch clamp method. Bradykinin (10μM) inhibited I_Ca in TG neurons. Maximum inward I_Ca was reduced by 26% by bradykinin compared with the controls (n=13, p<0.05). Decreased I_Ca induced by bradykinin did not recover to the prestimulus level after washing out bradykinin. In contrast, histamine (100μM) increased I_Ca by 25% compared with controls (n=7,p<0.05) in an irreversible manner. Eugenol (250μM), commonly used to produce analgesia in dental clinics, decreased I_Ca to 22.6% (n=9,p<0.05) and this effect on the I_Ca was reversible. although the effect of eugenol on the I_Ca was consistent, the effects of the two pain-inducing agents, bradykinin and histamine, were different. Our results suggest that the modulation of I_Ca in TG neurons is not a decisive factor underlying the pain mechanism evoked by pain-inducing agents.
ISSN
1225-6390
Language
English
URI
http://hdl.handle.net/10371/47209
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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