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생체유래 골이식재 (OSC-B)의 안전성 및 유효성에 관한 연구

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Authors

박호남; 한상혁; 김경화; 이상철; 박윤정; 이상훈; 김태일; 설양조; 구영; 류인철; 한수부; 정종평

Issue Date
2005
Publisher
대한치주과학회
Citation
대한치주과학회지 2005;35:335-343.
Keywords
bovine bonebone regenerationcalvarial defect
Abstract
Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B). Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group. It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.
ISSN
0250-3352
Language
Korean
URI
http://uci.or.kr/G100:I100-KOI(KISTI1.1003/JNL.JAKO200521452724025)

https://hdl.handle.net/10371/47480
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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