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HLA and Graves' Disease in Korean
한국인에서 Graves병과 HLA

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Authors
Cho, Bo Youn; Rhee, Byong Doo; Lee, Dong Soo; Lee, Myong Sik; Kim, Geum Young; Lee, Hong Kyu; Koh, Chang-Soon; Min, Hun Ki; Lee, Munho
Issue Date
1987-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(1):22-27
Keywords
HLAGraves' disease
Abstract
The HLA-A, -B, -C and -DR antigen distribution in 137 and 128 Korean
patients with Graves' disease, respectively, was compared with that in 220 controls. The
frequency of HLA-B13, HLA-DR5 and HLA-DRw8 was significatly increased in patients with
Graves' disease. The relative risk for Graves' disease in the individuals with these HLA antigens
was calculated as 3,8, 4.4 and 2.3, respectively. Thus, genes promoting the development of
Graves' disease in Korean are positively associated with the B13, DR5 and DRw8 haplotypes.
However there was no significant correlation between the presence of these HLA antigens and
the clinical features such as age at onset, sex, weight of goiter, exophthalmos, titer of autoantibodies,
initial TBII values, and relapse and remission rates. Consequently, factors influencing
the clinical features and the course of Graves' disease do not have a strong association with
these HLA antigens.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5696
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.1 (1987)
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