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Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RME-ras cells
Cited 12 time in
Web of Science
Cited 12 time in Scopus
- Authors
- Issue Date
- 2006-04
- Publisher
- Elsevier
- Citation
- CANCER LETTERS, 235 (2006), 53-59.
- Keywords
- RK3E ; k-ras ; Tumor model ; Sprague–Dawley rat
- Abstract
- Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague–Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.
- ISSN
- 0304-3835
- Language
- English
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