Immunohistochemical Study of So-called Sclerosing Hemangioma of the Lung

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Oh, Young-Lyun; Kim, Woo-Ho; Kim, Chul-Woo; Ham, Eui-Keun
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Seoul National University College of Medicine
Seoul J Med 1992;33(4):247-252
Lung neoplasmSclerosing hemangiomaBasement membraneImmunohistochemistry
The origin of tumor cells composing sclerosing hemangioma of the lung
has been extensively studied by many researchers, but it is still obscure. We analyzed
seven cases of sclerosing hemangioma of the lung from the files of Seoul National University
Hospital, Department of Pathology by immunohistochemical staining as well as
histologic observation. The tumors are composed of two kinds of cells; the epithelial
cells lining the papillary area are cytokeratin( +) and vimentinl -), while subepithelial
tumor cells are cytokeratin( -) and vimentinl +). Two kinds of cells are separated by
basement membrane, visualized by type IV collagen monoclonal antibody. The angiomatous
and solid areas are devoid of cytokeratin( +) epithelial cells and basement
membrane is not formed beneath the blood-filled cysts. The epitheial cells are frequently
seen at the periphery of the tumor, where the epithelial cells maintain their
pseudostratified and ciliated character of bronchiolar lining epithelium. The above
findings suggest that the epithelial cells would not be tumor cells but an entrapped mucosa,
and that the tumor cells be not of epithelial origin.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 33 No.4 (1992)
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