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동종 뇌하수체 전엽 추출물의 반복주사에 의한 백서 뇌하수체 전염 병변에 관한 병리조직학적 및 혈청학적 연구 : A serologic and histopathologic study on anterior lobe of pituitary in rats immunized with extracts of isologous rat anterior pituitary in Freund's adjuvant and pertussis vaccine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현순 | - |
dc.date.accessioned | 2009-08-09T12:55:15Z | - |
dc.date.available | 2009-08-09T12:55:15Z | - |
dc.date.issued | 1977-09 | - |
dc.identifier.citation | Seoul J Med, Vol.18 No.3, pp. 184-194 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6640 | - |
dc.description.abstract | An experimental study was made to develop an
animal model of autoimmune hypophysitis. Thirty rats were used. They were immunized with extracts of isologous rat anterior pituitary in Freund's complete adjuvant together with pertussis vaccine. The following results were obtained. Almost all of the pituitary antisera of the animals tested disclosed single precipitation line with pituitary extracts with Ouchterlony double diffusion gel technique. Triiodothyronine (T3) radioimmunoassy of five immunized rat sera failed to reveal any significant value compared with that of normal control sera. In group I animal group. architectures of the anterior lobe of the pituitary were relatively well preserved only focally showing minimal lymphocyte infiltration in three cases, but in group II. conspicuous lesion could be identified in six cases demonstrating architectural disconfigurat ion. cytolysis and degranulation of pituitary parenchymal cells as well as inflammatory cell (lymphocytes) infiltration. No specific lesions were noted in other organs and tissues examined. The results of this experiment suggest that human hypophysit.is might be understood along the line of autoimmunity. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 동종 뇌하수체 전엽 추출물의 반복주사에 의한 백서 뇌하수체 전염 병변에 관한 병리조직학적 및 혈청학적 연구 | - |
dc.title.alternative | A serologic and histopathologic study on anterior lobe of pituitary in rats immunized with extracts of isologous rat anterior pituitary in Freund's adjuvant and pertussis vaccine | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Lee, Hyun Soon | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 194 | - |
dc.citation.number | 3 | - |
dc.citation.pages | 184-194 | - |
dc.citation.startpage | 184 | - |
dc.citation.volume | 18 | - |
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