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Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes

Cited 56 time in Web of Science Cited 59 time in Scopus
Authors
Kim, Sangmin; Kim, Yoonkyung; Kim, Ji Eun; Cho, Kwang Hyun; Chung, Jin Ho
Issue Date
2007-10-24
Publisher
Elsevier
Citation
Phytomedicine. 15(5), 340-347
Keywords
Berberine/chemistry/*pharmacologyCells, CulturedGene Expression Regulation/drug effectsHumansInterleukin-6/*antagonists & inhibitors/genetics/metabolismKeratinocytes/*drug effects/metabolismMatrix Metalloproteinase 9/*antagonists & inhibitors/genetics/metabolismMolecular StructurePyridines/*toxicity
Abstract
Berberine is a plant ingredient that has anti-inflammatory and anti-oxidative effects. Matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) are known to be highly induced by ultraviolet (UV) light and may play important roles in UV-induced skin inflammation and the skin aging process. In this study, we investigated the effects of berberine on MMP-9 and IL-6 expression in normal human keratinocytes (NHK). Our results demonstrated that berberine dose-dependently inhibited basal and TPA-induced expression and activity of MMP-9, and also suppressed TPA-induced IL-6 expression. Berberine prevented TPA-induced ERK activation and AP-1 DNA binding activity. Therefore, berberine may be used as an effective ingredient for anti-skin aging products, which can prevent skin inflammation and the degradation of extracellular matrix proteins, including collagen, by MMPs.
ISSN
1618-095X (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17951041

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B7GVW-4PYYG36-2-9&_cdi=20441&_user=168665&_orig=search&_coverDate=05%2F15%2F2008&_sk=999849994&view=c&wchp=dGLbVzW-zSkWb&md5=c8a35aac76283ba4a29071482dfdf0a7&ie=/sdarticle.pdf

http://hdl.handle.net/10371/67531
DOI
https://doi.org/10.1016/j.phymed.2007.09.011
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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