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Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes
Cited 67 time in
Web of Science
Cited 72 time in Scopus
- Authors
- Issue Date
- 2007-10-24
- Publisher
- Elsevier
- Citation
- Phytomedicine. 15(5), 340-347
- Keywords
- Berberine/chemistry/*pharmacology ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-6/*antagonists & inhibitors/genetics/metabolism ; Keratinocytes/*drug effects/metabolism ; Matrix Metalloproteinase 9/*antagonists & inhibitors/genetics/metabolism ; Molecular Structure ; Pyridines/*toxicity
- Abstract
- Berberine is a plant ingredient that has anti-inflammatory and anti-oxidative effects. Matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) are known to be highly induced by ultraviolet (UV) light and may play important roles in UV-induced skin inflammation and the skin aging process. In this study, we investigated the effects of berberine on MMP-9 and IL-6 expression in normal human keratinocytes (NHK). Our results demonstrated that berberine dose-dependently inhibited basal and TPA-induced expression and activity of MMP-9, and also suppressed TPA-induced IL-6 expression. Berberine prevented TPA-induced ERK activation and AP-1 DNA binding activity. Therefore, berberine may be used as an effective ingredient for anti-skin aging products, which can prevent skin inflammation and the degradation of extracellular matrix proteins, including collagen, by MMPs.
- ISSN
- 1618-095X (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17951041
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B7GVW-4PYYG36-2-9&_cdi=20441&_user=168665&_orig=search&_coverDate=05%2F15%2F2008&_sk=999849994&view=c&wchp=dGLbVzW-zSkWb&md5=c8a35aac76283ba4a29071482dfdf0a7&ie=/sdarticle.pdf
https://hdl.handle.net/10371/67531
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