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Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro

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Authors
Kang, Kyoung-Ah; Zhang, Rui; Lee, Kyoung Hwa; Chae, Sungwook; Kim, Bum Joon; Kwak, Young Sook; Park, Jae Woo; Lee, Nam Ho; Hyun, Jin Won
Issue Date
2006-03-31
Publisher
Japan Radiation Reseach Society
Citation
J Radiat Res (Tokyo). 47(1): 61-68
Keywords
Algae, Brown/*metabolismAnimalsCell Survival/*drug effects/*radiation effectsCricetinaeCricetulusDNA Damage/*radiation effectsDose-Response Relationship, DrugFibroblasts/cytology/drug effects/*physiology/radiation effectsGamma RaysLipid Peroxidation/drug effectsPhloroglucinol/administration & dosage/*analogs & derivativesRadiation-Protective Agents/administration & dosageReactive Oxygen Species/*metabolism
Abstract
We studied the cytoprotective effect of triphlorethol-A against gamma-ray radiation-induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by gamma-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.
ISSN
0449-3060 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16571919

http://hdl.handle.net/10371/67901
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College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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