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Shank 2 expression coincides with neuronal differentiation in the developing retina

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Kim, Jeong Hun; Kim, Jin Hyoung; Yang, Esther; Park, Jae Hwan; Yu, Young Suk; Kim, Kyu Won
Issue Date
2009-03-21
Publisher
Korean Society of Medical Biochemistry
Citation
Exp Mol Med. 2009;41(4):236-242
Keywords
Adaptor Proteins, Signal Transducing/genetics/*metabolismAnimalsAstrocytes/cytology/metabolismCell Differentiation/*physiologyEnzyme ActivationExtracellular Signal-Regulated MAP Kinases/metabolism*Gene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLNerve Tissue Proteins/genetics/*metabolismNeurofilament Proteins/metabolismNeurons/cytology/*physiology*Retina/cytology/growth & development/physiologyRetinoblastoma/metabolism/pathology
Abstract
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation of Shank 2 expression with neuronal differentiation in the developing retina remains to be elucidated regardless of previous evidences of Shank 2 expression in retina. Herein, we demonstrated that with progression of development, Shank 2 is initially detected in the inner plexiform layer at P2, and then intensively detected in inner plexiform layer, outer plexiform layer, and ganglion cell layer at P14, which was closely colocalized to the neurofilament expression. Shank 2 was, however, not colocalized with glial fibrillary acidic protein. Shank 2 expression was increased in the differentiated retinoblastoma cells, which was mediated by ERK 1/2 activation. Moreover, Shank 2 expression was colocalized with neurofilament at the dendritic region of cells. In conclusion, our data suggests that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina.
ISSN
1226-3613 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19299912

http://synapse.koreamed.org/Synapse/Data/PDFData/0061EMM/emm-41-236.pdf

http://hdl.handle.net/10371/68219
DOI
https://doi.org/10.3858/emm.2009.41.4.026
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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