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Diagnostic accuracy of CT-guided core biopsy of ground-glass opacity pulmonary lesions
Cited 67 time in
Web of Science
Cited 80 time in Scopus
- Authors
- Issue Date
- 2007-12-21
- Publisher
- American Roentgen Ray Society
- Citation
- AJR Am J Roentgenol. 2008; 190(1):234-239
- Keywords
- Adult ; Aged ; Biopsy/*methods ; Diagnosis, Differential ; False Negative Reactions ; Female ; Humans ; Lung Diseases/diagnosis/pathology ; Lung Neoplasms/*pathology/*radiography ; Male ; Middle Aged ; Precancerous Conditions/*pathology/*radiography ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed/*methods
- Abstract
- OBJECTIVE: The purpose of our study was to evaluate the accuracy of CT-guided percutaneous core biopsy of ground-glass opacity (GGO) pulmonary lesions. MATERIALS AND METHODS: The study included 50 patients (24 men, 26 women; age range, 43-78 years) who had a GGO pulmonary lesion and underwent CT-guided core biopsy. Diagnostic accuracy was compared between two groups according to lesion size (< 2 cm vs > or = 2 cm) and GGO component (> 90% vs 50-90%). Each case was reviewed for complications, including pneumothorax, thoracostomy tube insertion, and hemoptysis. RESULTS: Malignancy was finally diagnosed in 33 patients, including three who underwent repeated biopsies, with 33 true-positive and three false-negative findings for an overall sensitivity of 92% (33/36). A benign lesion was finally diagnosed in 10 patients with one false-positive result, for a specificity of 90%. Two benign lesions without confirmative diagnosis because of loss of follow-up and five nondiagnostic samples were excluded from the calculations of sensitivity, specificity, and diagnostic accuracy. The overall diagnostic accuracy was 91%, with a positive predictive value of 97% and a negative predictive value of 75%. Sensitivity and accuracy were not significantly different between the two groups of lesion size and GGO components (p = 0.0491). Ten (18%) patients had pneumothorax, with one (2%) requiring placement of a thoracostomy tube. Mild hemoptysis occurred in seven (13%) patients. CONCLUSION: CT-guided core biopsy of GGO lesions can yield high diagnostic accuracy and acceptable complication rates approaching those of solid lesions.
- ISSN
- 1546-3141 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18094317
http://www.ajronline.org/cgi/reprint/190/1/234.pdf
https://hdl.handle.net/10371/68352
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