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Absence of long-term depression in the visual cortex of glutamic Acid decarboxylase-65 knock-out mice.

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Authors
Choi, Se-Young; Morales, Bernardo; Lee, Hey-Kyoung; Kirkwood, Alfredo
Issue Date
2002-07
Publisher
Society for Neuroscience
Citation
Journal of Neuroscience, 22(13):5271–5276
Keywords
critical periodsynaptic plasticityGABAneocortexIPSCsynaptic inhibition
Abstract
Long-term depression (LTD) is widely considered a mechanism for experience-induced synaptic weakening in the brain. Recent in vivo studies on glutamic acid decarboxylase [GAD 65 (/)] knock-out mice indicates that GABAergic synaptic inhibition is also required for the normal weakening of deprived inputs in the visual cortex. To better understand how GABAergic inhibition might control plasticity, we assessed the status of synaptic inhibition and LTD in visual cortical slices of GAD 65 knock-out mice. We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (/) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (/) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (/) mice. These results suggest that a certain inhibitory tone is required for the induction of LTD in visual cortex. We propose that the lack of visual cortical LTD in GAD 65 (/) may account for the lack of experience-dependent plasticity in these mice.
ISSN
0270-6474
Language
English
URI
http://hdl.handle.net/10371/68687
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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