SHERP

Signaling pathways of the early differentiation of neural stem cells by neurotrophin-3

Cited 0 time in webofscience Cited 35 time in scopus
Authors
Lim, Myung-Shin; Nam, Sang-Hyun; Kim, Sun-Jung; Kang, Seog-Youn; Lee, Yong Soon; Kang, Kyung-Sun
Issue Date
2007-04-18
Publisher
Elsevier
Citation
Biochem. Biophys. Res. Commun. 357 (2007) 903-909
Keywords
Neural stem cellsNeurotrophin-3Neuronal differentiationNeurite outgrowthAktERKp38
Abstract
Neurotrophin-3 (NT-3) is well known to play an important role in facilitating neuronal survival and differentiation during development. However, the mechanisms by which neurotrophin-3 promotes prolonged Akt/MAPK signaling at an early stage are not well understood. Here, we report that NT-3 works at an early stage of neuronal differentiation in mouse neural stem cells (NSCs). After treatment with NT-3 for 12 h, more NSCs differentiated into neurons than did untreated cells. These findings demonstrated that stimulation with NT-3 causes NSCs to differentiate into neurons through a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and the phosphorylated extracellular signal-regulated kinase (ERK) pathway. In addition, treatment with NT-3 induced neurite outgrowth by specific phosphorylation of p38 MAPK, which was accompanied by neuronal differentiation. Taken together, these results suggest that NT-3, along with the Trk C receptors in NSCs, might lead to the survival and neuronal differentiation of NSCs via two distinct downstream signaling pathways at an early stage of neuronal differentiation.
ISSN
0006-291X
Language
English
URI
http://hdl.handle.net/10371/6959
DOI
https://doi.org/10.1016/j.bbrc.2007.04.045
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse