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"Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazz

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Authors
Choi, Youngnim; Kim, Jeong J; Lee, Byung E; Jung, Dong S; Kim, Se Won; Ko, Seon Yle; Baek, Dong Heon; Chang, Sun Hwa
Issue Date
2004-12
Publisher
Korean Acadamy of Oral Biology
Citation
International Journal of Oral Biology 29:137-144
Keywords
disease modifying anti-rheumatic(DMARD)albizzia julibrissinactivated T cellapoptosiscaspase-8
Abstract
Although there are many disease modifying antirheumatic drugs (DMARDs) available, more safe and effective reagents have yet to be developed. Activated T cells make good targets for DMARD therapy. Therefore, we screened over fifty herbal extracts, and identified that water extract from the stem bark of Albizzia julibrissin selectively killed activated T cells but not naive splenocytes, in vitro. Wb3-3, obtained by further extraction and column chromatography to maximize selective activity, was used for further investigation. Annexin-V and caspase activity assay revealed that WB3-3 killed activated T cells by inducing apoptosis, which was mediated through mainly caspase-8 rather than caspase-9. The effect of WB3-3 in vivo was conlirmed by the elimination of V8- but no V6-T cells following activation with Streptococcal Enterotoxin B (SEB). Furthermore, WB3-3 inhibited neither CD25 upregulationnor proliferative response, and rather increased IL-2 secretion during Con A activation of naive T cells.Our results imply the potential of WB3-3 to include a lead compound for a new immunoregulatory drug.
ISSN
1226-7155
Language
English
URI
http://hdl.handle.net/10371/69784
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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