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N-methyl-N'-nitro-N-nitrosoguanidine 경구 투여에 의하여 발생한 흰쥐 전위의 편평 상피성 종양 -병리조직학적 관찰을 통한 편평 상피종양의 조직발생 추정 - : A Histopathologic Observation on Squamous Cell Neoplasm of the Forestomach in Rats by Peroral Administration of N-methyl-N'-nitro-N-nitrosoguanidine
DC Field | Value | Language |
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dc.contributor.author | 김우호 | - |
dc.contributor.author | 김용일 | - |
dc.contributor.author | 김진복 | - |
dc.date.accessioned | 2009-08-13T05:57:26Z | - |
dc.date.available | 2009-08-13T05:57:26Z | - |
dc.date.issued | 1983-12 | - |
dc.identifier.citation | Seoul J Med, Vol.24 No.4, pp. 371-379 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7150 | - |
dc.description.abstract | A histopathologic study on experimentally induced
squamous cell neoplasm of the forestomach in rats by peroral administration of N-methyl-N'-nitro-Nnitrosoguanidine( MNNG) was carried out to clarify the morphologic characteristics and nature of its carcinogenesis. A total of 160 rats were divided into two groups: 130 of experimental group were administered with drinking water containing 83ug/ml MNNG, and 30 control rats with distilled water. After 37 weeks of exposure to MNl'\G, the animals were sacrified and examined. Among the 130 experimetal group, 100 survived more than 32 weeks. Squamous cell papillomas were found in 24 rats(24%). and squamous cell carcinoma in 4 rats (4;'6), one of which was carcinoma in situ. Besides the neoplastic growth, reactive proliferation of the squamous cells such as acanthosis. hyperkeratosis and perakeratosis were frequent associations with or without atypical changes of the basal cells. The possible relationship between these reactive and neoplastic lesions was discussed based on the finding that all experimental animals start with the development of benign reactive and proliferative changes which are subsequently accompanied by cellular atypism as well as papillomatous growth to result in carcinomatous transformation. The proposed histogenesis was compared with that in glandular stomach. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | N-methyl-N'-nitro-N-nitrosoguanidine 경구 투여에 의하여 발생한 흰쥐 전위의 편평 상피성 종양 -병리조직학적 관찰을 통한 편평 상피종양의 조직발생 추정 - | - |
dc.title.alternative | A Histopathologic Observation on Squamous Cell Neoplasm of the Forestomach in Rats by Peroral Administration of N-methyl-N'-nitro-N-nitrosoguanidine | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Kim, Woo Ho | - |
dc.contributor.AlternativeAuthor | Kim, Yong Il | - |
dc.contributor.AlternativeAuthor | Kim, Jin-Pok | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 379 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 371-379 | - |
dc.citation.startpage | 371 | - |
dc.citation.volume | 24 | - |
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