급성 백혈병 환아의 피문(Dermatoglyphics)에 관한 연구
Dermatoglyphics in Children with Acute Leukemia

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서울대학교 의과대학
Seoul J Med 1976;17(1):27-33
There have been a number of apparently conflicting
studies on the dermatoglyphics of children with
leukemia. Some investigators reported statistically
significant differences in dermal pattern frequencies
and suggested dermatoglyphic findings are valuable
in identifying individuals with increased risk of
leukemia. In contrast, other workers believed that
dermatog Iyphic abnormalities of leukemic patients
had no diagnostic significance.
Since all of these findings were obtained on Caucasian
populations and it is well known fact that
there are racial differences in dermatoglyphic
patterns the present study was undetaken to survey
derrnatog lyphics of leukemic children and compare
with those of normal controls residing in this region.
The subjects studied include 30 children (IS boys
and 15 girls) with acute leukemia, 28 mothers of
patients and 30 normal control children of similar
age and sex. The patients ranged in age from 7
months to 12 years. The diagnosis of acute leukemia
was confirmed by bone marrow biopsy in all
patients at the first admission to the Pediatric
Ward of Sso rl National University Hospital between
July 1973 to December 1975.
The following parameters were examined: dermal
patterns of distal phalanges of digits (whorls, ulnar
loops, radial loops, and arches); digital pattern
intensity indcies: palmar flexion creases (normal,
complete and partial simian lines, and Syndney line); hypothenar, thenar/I-, 1,-, I" -1.- and hallucal-
area patterns; axial triradius (proximal and
distal); and presence or absence of clinodactyly of
little fingers. The data were statistically analysed
by means of the x' and Student's t tests.
The dermal patterns of digits in children with
acute leukemia did not differ those of normal control
children. The mothers of patients, however,
had significantly more arches on their fingers
(7.1%). There was also no difference in digital
pattern intensity indicies in three groups.
There was definite increase in incidence (40.0%)
of anomalous palmar flexion creases (complete and
partial simian lines) in children with acute leukemia.
Frequencies of simian lines in the normal
control children and mothers of leukemic children
were 13.3% and 7.1%, respectively. Sydney line
was not observed in all three groups.
Evaluation of dermal pattern frequencies in hypothenar-,
thenar/I-,I,-, 1,-, 1,- and hallucal-area
showed no significant differences in the patients,
mothers, and control groups. Incidences of axial
triradius (proximal and distal) and clinodactyly
likewise revealed no difference.
The results suggested that dermatoglyphic analysis
may not be a useful diagnostic aid in identifying
individuals who have increased constitutional susceptibility
to leukemogenesis.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 17 No.1 (1976)
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