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일부 무의촌지역과 병원에서 분리한 K. pneumoniae의 항균제 감수성에 관한 연구
Studies on the Antimicrobic Susceptibility of K. pneumoniae isolated from Doctorless Areas and Seoul Nattonal University Hospital

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Authors
장우현; 김익상; 이광호; 신희섭; 임정규
Issue Date
1979-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1979;20(2):92-103
Abstract
58 strains of K. pneumoniae isolated from residents
of doctor!ess areas in Korea from 1976 to 1977 and
67 strains of K. pneumoniae isolated from patients
of Seoul National University Hospital from 1975 to
1977 were examined for susceptibility to 14 antimicrobics
by agar dilution method.
The susceptibility of two groups to each antimicrobics
were compared and incidence of resistant strains
in each antimicrobics, incidence of multiple resistant
strains and correlations in the antimicrobic susceptibility
of 125 strains of K. pneumoniae among 14
antimicrobics were analyzed.
The results obtained were as follows.
1. The mean MIC of Ampicillin, Tetracyline,
Oxytetracycline, Kanamycin and Streptomycin to the
K. pneumoniae isolated from patients of Seoul National
University Hospital were 2. 1 to 2.8 times higher than
those to the K. pneumoniae isolated from residents of
doctorless areas.
2. The mean MIC of Penicillin, Doxycycline and
Cotrimoxazole to the K. pneumoniae isolated from
patients of Seoul National University Hospital were
1. 4 to 1. 7 times higher than those to the K. pneumoniae
isolated from residents of doctorless areas.
3. Tl:ere wcre no significant differences in suscep·
tibility to Carbenicillin, Cephalexin, Minocycline,
Gentamicin, and Erythromycin respectively between
K. pneumoniae isolated from patients of Seoul Nationa!
University Hospital and those from residents of doctorless
arease.
4. Incidence of resistant strains In K. pneumoniae isolated from Seoul National University Hospital was
the highest with Troleandomycin (100%) and Erythromycin
(100%) followed by Carbenicillin (94.0%),
Penicillin (53.7%), Minocycline (46.3%), Ampicillin
(44. %), Oxytetracycline (23.9%), Tetracycline(22.4
%), Doxycycline (20.9%), Streptomycin (22%),
Kanamycin (16.4%), Gentamicin (7.4%), Cephalexin
(1. 5%) and Cotrimoxazole (0%).
5. Frequency of resistant strain in K. pneumoniae
isolated from residents of doctorless areas was the
highest with Troleandomycin (100%) and Erythromycin
(100%) followed by Carbenicillin (98.3%),
Penicillin (44.8%), Minocycline (29.3%), Ampicillin
(22.4%), Doxycycline (1. 7%), Cephal exin (1. 7%),
Tetracycline (0%), Oxytetracycline (0%), Kanamycin
(0%), Gentamicin (0%), Streptomycin (0%) and
Cotrimoxazole (0%).
There were significant differences in the incidence of
resistant strains between two groups of K. pneumoniae
with Ampicillin, Tetracycline, Oxytetracycline, Minecycline,
Kanamycin, Gentamicin and Streptomycin
(p<0.05).
6. In study with Ampicillin, Gentamicin, Kanamycin,
Streptomycin. Tetracycline, Minocycline, Cephalexin,
and Cotrirnoxasole, there were no multiple resistant
strains in K. pneumoniae isolated from doctorless
areas, while 23 strains of K. pneumoniae isolated
from patients of Seoul National University Hospital
showed multiple resistance.
7. There were high correlation in susceptibility of
125 strains of K. pneumoniae among Tetracycline,
Oxytetracycline and Doxycycline (correlation coefficient
O. 87~0. 94), but there were relatively low correlation
in susceptibility between Minocycline and other
3 tetracvclines (Tetracycline, Oxytetracycline and
Doxycycline).
Correlation coefficient of susceptibility among penicillin
analogues (Penicillin, Ampicillin and Carbenicillin)
ranged between O. 30~0. 78.
Correlation coefficient of susceptibility between Streptomycin
and 3 tetracyclines (Tetracycline, Oxytetracycline
and Doxycycline) ranged between O. 76~
0.82.
Correlation coefficient of susceptibility between
Kanamycin and Streptomycin were 0.84.
Language
Korean
URI
http://hdl.handle.net/10371/7208
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 20 No.2 (1979)
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