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Effects of poly(lactic-co-glycolic acid) (PLGA) degradability on the apatite-forming capacity of electrospun PLGA/SiO2-CaO nonwoven composite fabrics
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- Authors
- Issue Date
- 2010-04
- Publisher
- Wiley-Blackwell
- Citation
- Journal of Biomedical Materials Research - Part B Applied Biomaterials 2010;93:218-226
- Keywords
- Bioactivity ; Degradability ; Electrospinning ; PLGA ; SiO2-CaO
- Abstract
- We investigated the effects of poly(lactic-co-glycolic acid) (PLGA) degradability on the apatite-forming ability of electrospun PLGA/SiO 2-CaO gel composite fabric. Two PLGA copolymer compositions with low and high degradability were used in experiments. A nonwoven polymer/ceramic composite fabric composed of randomly mixed microsized biodegradable PLGA fibers and nanosized bioactive SiO2-CaO gel fibers was prepared using a simultaneous electrospinning method. A 17 wt.% PLGA solution was prepared using 1,1,3,3-hexafluoro-2-propanol as a solvent, while the SiO2-CaO gel solution was prepared via a condensation reaction following hydrolysis of tetraethyl orthosilicate under acidic conditions. PLGA and SiO2-CaO gel solutions were spun simultaneously with two separate nozzles under electric fields of 1 and 2 kV/cm using two syringe pumps with flow rates of 7.5 and 5 mL/h, respectively. As controls, low and high degradable PLGA and SiO 2-CaO gel nonwoven fabrics were also made by the same methods. The five nonwoven fabrics that were produced were exposed to simulated body fluid (SBF) for 1 week. SBF exposure resulted in the deposition of a layer of apatite crystals on the surfaces of both the SiO2-CaO gel and the low degradable PLGA/SiO2-CaO gel composite fabrics, but not on the low and high degradable PLGA or the high degradable PLGA/SiO2-CaO gel composite fabrics. The results are explained in terms of the acidity of the PLGA degradation products, which could have a direct influence on apatite dissolution.
- ISSN
- 1552-4973
- Language
- English
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