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(18)F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma

Cited 42 time in Web of Science Cited 50 time in Scopus
Authors
Lee, Jeong Won; Kang, Keon Wook; Park, Sung-Hye; Lee, Sang Mi; Chung, June-Key; Lee, Dong Soo; Lee, Myung Chul; Paeng, Jin Chul
Issue Date
2009-10
Publisher
SPRINGER
Citation
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; Vol.36 10; 1574-1582
Keywords
MeningiomaPositron emission tomography (PET)(18)F-fluorodeoxyglucose (FDG)PrognosisRecurrence
Abstract
Purpose The purpose of this study was to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection. Methods Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled. All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34 +/- 20 months. The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma. Further, univariate analysis with the log-rank test was performed to assess the predictive factors of meningioma recurrence. Results The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p = 0.002) and significantly correlated with the MIB-1 labeling index (r = 0.338, p = 0.009) and mitotic count of the tumor (r = 0.284, p = 0.03). The ROC analysis revealed that the TGR of 1.0 was the best cutoff value for detecting high-grade meningioma with a sensitivity of 43%, specificity of 95%, and accuracy of 81%. Of 59 patients, 5 (9%) had a recurrent event. In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence. The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p = 0.0003) Conclusion FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.
ISSN
1619-7070
Language
English
URI
http://hdl.handle.net/10371/76621
DOI
https://doi.org/10.1007/s00259-009-1133-x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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