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Transmission of Seasonal Outbreak of Childhood Enteroviral Aseptic Meningitis and Hand-foot-mouth Disease

Cited 31 time in Web of Science Cited 33 time in Scopus
Authors
Park, Sue K.; Park, Boyoung; Ki, Moran; Kim, Ho; Jung, Cheoll; Choi, Sung-Min; Lee, Dong Seok; Kim, Moon Kyu; Cheong, Hae-Kwan; Ko, Joon Tae; Kim, Doo-Kwun; Sohn, Young Mo; Lee, Kwan
Issue Date
2010-05
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 5; 677-683
Keywords
Meningitis, AsepticHand, Foot and Mouth DiseaseWaterborne InfectionEpidemiologyEnterovirusDisease Transmission
Abstract
This study was conducted to evaluate the modes of transmission of aseptic meningitis (AM) and hand-foot-mouth disease (HFMD) using a case-control and a case-crossover design. We recruited 205 childhood AM and 116 HFMD cases and 170 non-enteroviral disease controls from three general hospitals in Gyeongju, Pohang, and Seoul between May and August in both 2002 and 2003. For the case-crossover design, we established the hazard and non-hazard periods as week one and week four before admission, respectively. In the case-control design, drinking water that had not been boiled, not using a water purifier, changes in water quality, and contact with AM patients were significantly associated with the risk of AM (odds ratio [OR]=2.8, 2.9, 4.6, and 10.9, respectively), while drinking water that had not been boiled, having a non-water closet toilet, changes in water quality, and contact with HFMD patients were associated with risk of HFMD (OR=3.3, 2.8, 6.9, and 5.0, respectively). In the case-crossover design, many life-style variables such as contact with AM or HFMD patients, visiting a hospital, changes in water quality, presence of a skin wound, eating out, and going shopping were significantly associated with the risk of AM (OR=18.0, 7.0, 8.0, 2.2, 22.3, and 3.0, respectively) and HFMD (OR=9.0, 37.0, 11.0, 12.0, 37.0, and 5.0, respectively). Our findings suggest that person-to-person contact and contaminated water could be the principal modes of transmission of AM and HFMD.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/76897
DOI
https://doi.org/10.3346/jkms.2010.25.5.677
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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