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Differences in Lipid Peroxidation and Cu,Zn-Superoxide Dismutase in the Hippocampal CA1 Region Between Adult and Aged Dogs

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Authors
Hwang, In Koo; Yoon, Yeo Sung; Yoo, Ki-Yeon; Li, Hua; Choi, Jung Hoon; Kim, Dae Won; Yi, Sun Shin; Sung, Je Kyeong; Lee, In Se; Won, Moo-Ho
Issue Date
2008
Publisher
Japanese Society of Veterinary Science
Citation
J. Vet. Med. Sci. 70: 273-277
Keywords
adult and aged dogCuZn-superoxide dismutasehippocampal CA1 regionlipid peroxidation
Abstract
Reactive oxygen species have been long associated with oxidative stress relevant to many pathological damages. In brain, 4-hydroxy-2E-nonenal (HNE), a major cytotoxic end product of lipid peroxidation, is produced. In contrast, superoxide dismutase (SOD), one of the major antioxidant enzymes, protects neurons from oxidative stress. The aim of this study is to observe differences in the distribution of HNE and Cu,Zn-superoxide dismutase (SOD1) in the hippocampal CA1 region of adult (2-3 years of age) and aged (10-12 years of age) dogs. The HNE immunoreactivity and protein level in the CA1 region were significantly high in the aged dogs compared to those in the adult dogs. SOD1 immunoreactivity and its protein level were also higher in the aged dogs than those in the adult dogs. However, there were not significant differences in NeuN (a neuron-specific soluble nuclear antigen) immunoreactivity in CA1 neurons between the adult and aged dogs. These differences may be associated with oxidative stress in aged dogs compared to that in adult dogs.
ISSN
0916-7250 (print)
1347-7439 (online)
Language
English
URI
http://hdl.handle.net/10371/7782
DOI
https://doi.org/10.1292/jvms.70.273
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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