S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder
- Lee, Kyu Young; Song, Joo Yun; Kim, Se Hyun; Kim, Seong Chan; Ahn, Yong Min; Kim, Yong Sik; Joo, Eun-Jeong
- Issue Date
- PERGAMON-ELSEVIER SCIENCE LTD
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 7; 1196-1201
- Genes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder A single nucleotide polymorphism (SNP) in the 3`-flanking region of CLOCK (3111T/C, rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar disorder in 260 patients and 350 controls in a Korean population CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder (P=0.012, P=0 033, respectively) Morningness/eveningness (M/E) was evaluated using the Composite Scale of Morningness (CSM) in 108 patients with bipolar disorder In the subgroup analysis of the highest and lowest 25th percentile of M/E scores, significantly more C allele carriers were found among extreme evening types than among extreme morning types (P= 0.041) After correcting for age. C allele carriers had lower M/E scores than those carrying the T/T genotype, but the association was not statistically significant We also analyzed the association between age at onset (AAO) and CLOCK 3111T/C in the bipolar disorder group, and no association was found Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder. Further studies with larger samples and more polymorphisms are necessary (C) 2010 Elsevier Inc All rights reserved
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