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The Replication of Egr3 as a Potential Susceptibility Gene for Schizophrenia in Korean Patients with Schizophrenia

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Authors
Kim, Se Hyun; Song, Joo Yun; Joo, Eun-Jeong; Lee, Kyu Young; Kim, Yong Sik; Ahn, Yong Min
Issue Date
2010-05-01
Publisher
ELSEVIER SCIENCE INC
Citation
BIOLOGICAL PSYCHIATRY; Vol.67 9; 164S-164S
Abstract
Background: Early growth response (Egr) genes play critical role in signal
transduction in the brain, which is involved in neuronal activation, brain
development, and synaptic plasticity. Egr3, a member of Egr gene family,
resides at the chromosomal location 8p21.3 and was suggested as a potential
susceptibility gene in schizophrenia from study with Japanese population,
which requires further replication with an independent sample.
Methods: We investigated the association of Egr3 and Egr2 genes with
schizophrenia in Korean patients with schizophrenia. Along with 350 healthy
individuals, a sample of 244 schizophrenia was analyzed.
Results: Among examined four SNPs of Egr3, SNP3 in the intron1 of Egr3 gene
showed significant association with schizophrenia (P = 0.0008, Chi2 = 11.156,OR = 1.493). In addition, ‘T-G-C-G’ haplotype of Egr3 was under-presented
in the patients with schizophrenia (P = 0.0073, Chi2 = 7.188, OR = 0.697).
However, association between SNPs of Egr2 and schizophrenia was not found.
Conclusions: These findings are in consistent with the previous genetic
association of Egr3 gene in Japanese cohorts, which could suggest Egr3 as a
compelling susceptibility gene in schizophrenia.
ISSN
0006-3223
Language
English
URI
http://hdl.handle.net/10371/78481
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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