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Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity

Cited 14 time in Web of Science Cited 13 time in Scopus
Authors
Shin, Hyun-Woo; Han, Doo Hee; Lim, Yune Sung; Kim, Hye Jung; Lee, Chul Hee; Rhee, Chae-Seo; Min, Yang-Gi; Kim, Dong-Young
Issue Date
2009-10
Publisher
MOSBY-ELSEVIER
Citation
OTOLARYNGOLOGY-HEAD AND NECK SURGERY; Vol.141 4; 442-447
Abstract
OBJECTIVE: To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloprotemase (TIMP-1) in nasal polyposis. STUDY DESIGN: A case-control study. SETTING: A tertiary referral center. SUBJECTS AND METHODS: The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosm staining were also performed and those expression levels were compared. RESULTS: Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group. CONCLUSION: The presence of AR may enhance the expression of MAV-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
ISSN
0194-5998
Language
English
URI
http://hdl.handle.net/10371/78520
DOI
https://doi.org/10.1016/j.otohns.2009.07.011
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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