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Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat

Cited 11 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Ha Na; Jeon, Gye Sun; Kim, Dong Woon; Cho, Ik-Hyun; Cho, Sa Sun
Issue Date
2010-01
Publisher
SPRINGER/PLENUM PUBLISHERS
Citation
NEUROCHEMICAL RESEARCH; Vol.35, No.1; 114-121
Keywords
Adenomatous polyposis coliBeta-cateninKainic acidGSK-3betaAstrocytesOligodendrocytes
Abstract
The adenomatous polyposis coli gene (APC) was initially identified through its link to colon cancer. It is associated with the regulation of cell cycle progression, survival, and differentiation of normal tissues. Recent studies have demonstrated that APC is also expressed in the adult brain at high levels. However, its role in glial cells under pathological progression remains unclear. In this study, we evaluated the expression of APC and its association with beta-catenin signaling pathway, following the induction of an excitotoxic lesion by kainic acid (KA) injection, which cause pyramidal cell degeneration. APC was predominantly present in oligodendrocytes in the normal brain, but was specifically associated with activated astrocytes in the KA-treated brain. Our quantitative analysis revealed that APC significantly increased from 1 day post lesion (PI), reached peak values at 3 days PI, and decreased thereafter. The phospho-GSK3 beta levels also showed similar spatiotemporal patterns while beta-catenin expression was reduced at 1 and then increasingly returned to normal levels at 3, 7 days PI. For the first time, our data demonstrate the injury-induced astrocytic changes in the levels of APC, GSK3 beta, and beta-catenin in vivo, which may actively be participate in cell adhesion and in the signaling pathway regulating cell survivals during brain insults.
ISSN
0364-3190
Language
English
URI
http://hdl.handle.net/10371/78681
DOI
https://doi.org/10.1007/s11064-009-0036-3
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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