Changes in Glial Fibrillary Acidic Protein Immunoreactivity in the Dentate Gyrus and Hippocampus Proper of Adult and Aged Dogs

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Hwang, In Koo; Choi, Jung Hoon; Li, Hua; Yoo, Ki-Yeon; Kim, Dae Won; Lee, Choong Hyun; Yi, Sun Shin; Sung, Je Kyeong; Lee, In Se; Yoon, Yeo Sung; Won, Moo-Ho
Issue Date
Japanese Society of Veterinary Science
J. Vet. Med. Sci. 70: 965-969
agingastrocytecanineglial fibrillary acidic proteinhippocampus
Astrocytes perform neuron-supportive tasks, repair and scarring process in the central nervous system. In this study, we
observed glial fibrillary acidic protein (GFAP), a marker for astrocytes, immunoreactivity in the dentate gyrus and hippocampus proper
(CA1–3 region) of adult (2–3 years of age) and aged (10–12 years of age) dogs. In the adult group, GFAP immunoreactive astrocytes
were distributed in all layers of the dentate gyrus and CA1–3 region, except in the stratum pyramidale of the CA1–3 region. In the aged
group, GFAP immunoreactivity decreased markedly in the molecular layer of the dentate gyrus. However, GFAP immunoreactivity in
the CA1–3 region increased in all layers, and the cytoplasm of GFAP immunoreactive astrocytes was hypertrophied. GFAP protein levels
in the aged dentate gyrus decreased; however, GFAP levels in the CA1–3 region increased. These results suggest that the morphology
of astrocytes and GFAP protein levels in the hippocampal dentate gyrus and CA1 region are changed, respectively, with age.
0916-7250 (print)
1347-7439 (online)
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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