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Receptor-Mediated Gene Delivery Using Chitosan Derivatives in Vitro and in Vivo

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Authors
Kim, Tae-Hee; Jiang, Hu-Lin; Nah, Jae-Woon; Cho, Myung-Haing; Akaike, Toshihiro; Cho, Chong-Su
Issue Date
2007-03-28
Publisher
Wiley-Blackwell
Citation
Macromol. Symp. 2007, 249-250, 137
Keywords
chitosanligand modificationnon-viral vectorreceptor-mediated gene deliverytransfection efficiency
Abstract
The development of an efficient targeted gene delivery system into cells is
an important strategy for the advancement of gene therapy. The targeted gene
delivery system is especially important in non-viral gene transfer which shows the
relative low transfection efficiency. And it also opens the possibility of selective
delivery of therapeutic plasmids to specific tissues. Chitosan has been investigated as
a non-viral vector because it has several advantages such as biocompatibility,
biodegradability and low toxicity with high cationic potential. However, low specificity
and low transfection efficiency of chitosan need to be overcome prior to clinical
trial. In this review, we focused on the specific ligand modification of chitosan for
enhancement of cell specificity and transfection efficiency via receptor-mediated
endocytosis in vitro and in vivo.
ISSN
1022-1360
Language
English
URI
http://hdl.handle.net/10371/8340
DOI
https://doi.org/10.1002/masy.200750323
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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