S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
- Kim, Bang Hyun; Won, Young Suk; Kim, Dae-Yong; Kim, Bora; Kim, Eun-Young; Yoon, Mijung; Oh, Goo Taeg
- Issue Date
- BMB Rep. 42, 91-95
- Peroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity.
To test this relationship, we divided female wildtype and
PPARα-deficient mice fed on a high fat diet into the following
groups: mock-operated, ovariectomized (OVX), and E2-treated.
The visceral white adipose tissue and plasma cholesterol levels
were increased significantly in wild type OVX and decreased in
the E2-treated group, but interestingly not in PPARα-deficient
mice. The mRNA levels of lipoprotein lipase in adipose tissue
were also increased in only wild type OVX and decreased significantly
in E2-treated mice. These novel results suggest the possibility
of signaling crosstalk between PPARα and E2, causing
obesity in vivo.
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