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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

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Authors
Kim, Bang Hyun; Won, Young Suk; Kim, Dae-Yong; Kim, Bora; Kim, Eun-Young; Yoon, Mijung; Oh, Goo Taeg
Issue Date
2008
Publisher
한국생화학분자생물학회 = Korean Society for Biochemistry and Molecular Biology
Citation
BMB Rep. 42, 91-95
Keywords
EstrogenLPLObesityPPARαSignaling crosstalk
Abstract
Peroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity.
To test this relationship, we divided female wildtype and
PPARα-deficient mice fed on a high fat diet into the following
groups: mock-operated, ovariectomized (OVX), and E2-treated.
The visceral white adipose tissue and plasma cholesterol levels
were increased significantly in wild type OVX and decreased in
the E2-treated group, but interestingly not in PPARα-deficient
mice. The mRNA levels of lipoprotein lipase in adipose tissue
were also increased in only wild type OVX and decreased significantly
in E2-treated mice. These novel results suggest the possibility
of signaling crosstalk between PPARα and E2, causing
obesity in vivo.
ISSN
1976-6696
Language
English
URI
http://hdl.handle.net/10371/8622
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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