SHERP

알카로이드계열 한약제의 간독성에 관한 실험적 연구 제1편 간거대세포현상
Hepatoxicity of Alkaloid Herb-Medicine in Korea Part 1. A Histologic Reappraisal of

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Authors
김용일
Issue Date
1972-09
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1972;13(3):167-175
Abstract
A histopathologic reappraisal of lasiocarpine(pyrrolizidine
alkaloid)-induced megalocytosis of the
liver on rats was carried out. as an attempt to
compare with similar hepatic cell alterations encountered
frequently among Koreans and to clarify
its biological significance on those phenomena.
Megalocytosis. a characteristic hepatic cell unrest,
was found in groups of lasiocarpine and p-dimethylaminoazobenzene
administration. but much advanced
in animals treated with lasiocarpine and p-dimethylaminoazobenzene
together, being progressive and
constant with prolongation of experimental duration
and regenerative activity of underlying hepatic
tissue.
Megalocytosis produced in rats was cytologically and histoioglcally quite similar or nearly identical
to those seen in 27 cases of liver biopsy materials
with history of taking herb-medicine in 23 Koreans.
It 섭i s 이0 f a따ulth야oIr냥 0때p미i띠nl너i o n that demonstration 이0f
hepatic mega띠loc야ytosis is one of important histologic
criteria to screen hepatotoxicity of herb‘ medicine
in Korea.
Language
Korean
URI
http://hdl.handle.net/10371/9268
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.3 (1972)
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