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공급자항원을 이용한 백서신장이식의 면역반응과 능동적증강
Immune Responsiveness and Active Enhancement of Rat Renal Allograft by Donor Specific Antigen

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Authors
김진복
Issue Date
1975-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1975;16(4):247-252
Abstract
Immunological modification of immune res
ponse in the organ recipient by either active
or passive enhancement has been experiment
ally showing a promise as a means of specific
biological immuno-suppression by Wilson et
al씨 15) and others. How-ever, precise method
of administration of antigen or specific antibody
is necessary. Active enhan-cement
of rat renal allograft survival by pretreatment
with 0.5 mg per kg of body weight
donor specific soluble LBNF1 splenic antigen
has achieved in Lewis recipient receiving
LBNF1 kidney. Renal transplantation waS
performed between Lewis inbred rats and
LewisXBrown Norway F1 hybrid. LBNF1
rats' kidneys were transplanted to adult
male Lewis rats weighing 350-450gm.
Immunological assay studies were performed
to detect the mechanism of immune
responsiveness in the actively enhanced,
long-survived 5 renal allograft recipients
(averag survial time is 64 days)
Language
English
URI
http://hdl.handle.net/10371/9442
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 16 No.4 (1975)
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