SHERP

정상 한국인 및 순환기질환에서의 혈청 과산화지질에 관한 연구
Study on Serum Lipid Peroxide Level in Normal Adult Koreans and Cardiovascular Diseases

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Authors
이영우; 유세화; 이성호
Issue Date
1981-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1981;22(4):513-524
Abstract
Lipid pcroxidation in vivo has been identified as a
basic deterioration reaction in c인llular mechanism of
aging process. Because of the damaging effects of lipid
peroxidation and of accumulation of its characteristic
product, this reaction is emphasized as one of
the most deteriorative reactions that results in damage
to cellular components. Lipid peroxide has been
suspected as they might play some role in the process
of athersclerosis and vascular complications of cardi
avascular discases.
To assess the role and responses of lipid peroxide
in cardiovascular disease , the author measured serum
lipid peroxide level in 172 cases of normal adult
Koreans and in patients with hypertension, coronary
heart disease , acute myocardial infarction and acute
stroke. The author measured lipid peroxide by fluorometry
according to the method after Yagi , with the
following conclusions.
1. The mean serum cholesterol level in normal
adult Koreans with ideal body weight is 170.8±36
3mg%, influenced by ages but not by sex.
2. The mean serum lipid peroxide level in normal
adult Koreans is 3. 11 土0 . 5 6 n mole MDA/ml, influeneed
by ages but not by sex
3. The serum lipid peroxide level is not significantly
elevated in patients with hypertension and
stable coronary heart diseases , but the serum cholesterol
and triglyceride levels in the patients are higher
than the normal population.
4. During the course of acute myocardial infarction
the serum lipid peroxide level is sharply elevated
initially and lowered rapidly. The serum cbolesterol
level is lowered slightly and recovered to initiallevel
in two weeks and the serum triglyceride level is
elevated slightly.
5. During the course of acute stroke syndrome the
serum lipid peroxide level is sharply elevated initially
and lowered rapidly. The serum cholesterol level
is lowered slightly and serum triglyceride level is
elevated during the initial two weeks
6. The serum lipid peroxide Ie、이 is not signifi·
cantly correlated to the serum cholesterol level in
health and in cardiovascular diseases
Language
Korean
URI
http://hdl.handle.net/10371/9532
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.4 (1981)
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