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Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens

Cited 29 time in Web of Science Cited 33 time in Scopus
Authors
Min, Wongi; Lillehoj, Hyun S.; Ashwell, Christopher M.; Tassell, Curtis P. van; Dalloul, Rami A.; Matukumalli, Lakshmi K.; Han, Jae Yong; Lillehoj, Erik P.
Issue Date
2005
Publisher
Humana Press
Citation
Molecular Biotechnology, vol.30 no.2, pp. 143-150
Keywords
Chickensintestinal lymphocytesexpressed sequence tag (EST)expression cDNA libraryEimeria
Abstract
Intraepithelial lymphocytes (IELs) play a critical role in protective immune response to intestinal pathogens such as Eimeria, the etiologic agent of avian coccidiosis. A list of genes expressed by intestinal IELs of Eimeria-infected chickens was compiled using the expressed sequence tag (EST) strategy. The 14,409 ESTs consisted of 1851 clusters and 7595 singletons, which revealed 9446 unique genes in the data set. Comparison of the sequence data with chicken DNA sequences in GenBank identified 125 novel clones. This EST library will provide a valuable resource for profiling global gene expression in normal and pathogen-infected chickens and identifying additional unique immune-related genes.
ISSN
1073-6085
Language
English
URI
https://hdl.handle.net/10371/100212
DOI
https://doi.org/10.1385/MB:30:2:143
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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