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Immune-related gene expression in two B-Complex disparate genetically inbred Fayoumi chicken lines following Eimeria maxima infection

Cited 47 time in Web of Science Cited 48 time in Scopus
Authors
Kim, D.K.; Lillehoj, H.S.; Hong, Y.H.; Park, D.W.; Lamont, S.J.; Han, Jae Yong; Lillehoj, E.P.
Issue Date
2008
Publisher
Oxford University Press
Citation
Poultry Science Journal, vol.87 no.3, pp. 433-443
Keywords
major histocompatibility complexFayoumiEimeria maximaimmune-relateddisease resistance
Abstract
To investigate the influence of genetic differences in theMHCon susceptibility to avian coccidiosis, M5.1 and M15.2 B-haplotype-disparate Fayoumi chickens were orally infected with live Eimeria maxima oocysts, and BW gain, fecal oocyst production, and expression of 14 immune-related genes were determined as parameters of protective immunity. Weight loss was reduced and fecal parasite numbers were lower in birds of the M5.1 line compared with M15.2 line birds. Intestinal intraepithelial lymphocytes from M5.1 chickens expressed greater levels of transcripts encoding interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, IL-12, IL-15, IL-17A, inducible nitricoxide synthase, and lipopolysaccharide-induced tumor necrosis factor-α factor and lower levels of mRNA for IFN-α, IL-10, IL-17D, NK-lysin, and tumor necrosis factor superfamily 15 compared with the M15.2 line. In the spleen, E. maxima infection was associated with greater expression levels of IFN-γ, IL-15, and IL-8 and lower levels of IL-6, IL-17D, and IL-12 in M5.1 vs. M15.2 birds. These results suggest that genetic determinants within the chicken MHC influence resistance to E. maxima infection by controlling the local and systemic expression of immune-related cytokine and chemokine genes.
ISSN
0032-5791
Language
English
URI
https://hdl.handle.net/10371/100256
DOI
https://doi.org/10.3382/ps.2007-00383
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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