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Sexually dimorphic gene expression in the chick brain before gonadal differentiation

Cited 31 time in Web of Science Cited 29 time in Scopus
Authors
Lee, S.I.; Lee, W.K.; Shin, J.H.; Han, B. Ku; Moon, S.; Cho, S.; Park, T.; Kim, H.; Han, Jae Yong
Issue Date
2009
Publisher
Oxford University Press
Citation
Poultry Science Journal, vol.88 no.5, pp. 1003-1015
Keywords
chickensexual brain differentiationdifferentially expressed genequantitative real-time polymerase chain reaction
Abstract
Biological bases for sexual differences in the brain exist in a wide range of vertebrate species, including chickens. Recently, the dogma of hormonal dependence for the sexual differentiation of the brain has been challenged. We examined whether sexually dimorphic gene expression in the brain precedes gonadal differentiation. Using the Affymetrix GeneChip Chicken Genome Array, we identified 42 female- and 167 male-enhanced genes that were differentially expressed in sex-specific brains from stage 29 chicken embryos. To confirm the efficacy of the microarray, and to investigate the stage-specific expression patterns of the identified genes, we used quantitative real-time PCR analysis. Our real-time PCR results for the differentially expressed genes agreed well with our microarray results. Thus, we postulate that these genes have potential roles in the sexual differentiation of neural function and development in chickens.
ISSN
0032-5791
Language
English
URI
https://hdl.handle.net/10371/100275
DOI
https://doi.org/10.3382/ps.2008-00197
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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