Browse

Molecular cloning and comparative analysis of immunoglobulin heavy chain genes from Phasianus colchicus, Meleagris gallopavo, and Coturnix japonica

DC Field Value Language
dc.contributor.authorChoi, Jin Won-
dc.contributor.authorKim, Jin-Kyoo-
dc.contributor.authorSeo, Hee Won-
dc.contributor.authorCho, Byung Wook-
dc.contributor.authorSong, Gwonhwa-
dc.contributor.authorHan, Jae Yong-
dc.date.accessioned2017-01-31T04:38:11Z-
dc.date.available2017-01-31T04:38:11Z-
dc.date.issued2010-
dc.identifier.citationVeterinary Immunology and Immunopathology, vol.136 no.3-4, pp. 248-256ko_KR
dc.identifier.issn0165-2427-
dc.identifier.urihttps://hdl.handle.net/10371/100291-
dc.description.abstractTo date, immunoglobulin (Ig) genes have only been fully characterized in a small number of aves, which pose a major obstacle to understanding Ig evolution. Thus, we cloned the cDNAs of three immunoglobulin classes, IgA, IgM, and IgY, from Phasianus colchicus, Coturnix japonica, and Meleagris gallopavo. Multiple sequence alignments revealed that the highest degree of sequence homology in all Ig classes was observed between pheasant and turkey whereas the degree of homology between the galliforms and non-galliforms was relatively low compared to that among the galliforms. When the constant region domains of the four human Ig classes were compared with the corresponding regions in aves, the average percent homology between human CH2 and avian CH3, and between human CH3 and avian CH4, was greater than between identical domains in IgA and IgY, which are in partial agreement with the hypothesis that the avian CH2 domain evolved to form the mammalian hinge via domain condensation. Phylogenetic analysis showed that the galliform Ig heavy chain constant regions were divided into quail and the common ancestor of chicken, turkey, and pheasant, and that chicken was separated from turkey and pheasant, which were grouped together. These results add to our knowledge of galliform Igs and the diversification of these genes.ko_KR
dc.language.isoenko_KR
dc.publisherElsevierko_KR
dc.subjectImmunoglobulin heavy chainko_KR
dc.subjectPheasantko_KR
dc.subjectQuailko_KR
dc.subjectTurkeyko_KR
dc.titleMolecular cloning and comparative analysis of immunoglobulin heavy chain genes from Phasianus colchicus, Meleagris gallopavo, and Coturnix japonicako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최진원-
dc.contributor.AlternativeAuthor김진규-
dc.contributor.AlternativeAuthor서희원-
dc.contributor.AlternativeAuthor조병욱-
dc.contributor.AlternativeAuthor송권화-
dc.contributor.AlternativeAuthor한재용-
dc.identifier.doi10.1016/j.vetimm.2010.03.014-
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse