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The Distribution of Neuron-Specific Gene Family Member 1 in Brain and Germ Cells: Implications for the Regulation of Germ-Line Development by Brain

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dc.contributor.authorRengaraj, Deivendran-
dc.contributor.authorLee, Bo Ram-
dc.contributor.authorPark, Kyung Je-
dc.contributor.authorLee, Sang In-
dc.contributor.authorKang, Kyung Soo-
dc.contributor.authorChoi, Jin Won-
dc.contributor.authorKang, Seok Jin-
dc.contributor.authorSong, Gwonhwa-
dc.contributor.authorHan, Jae Yong-
dc.date.accessioned2017-01-31T06:15:05Z-
dc.date.available2017-01-31T06:15:05Z-
dc.date.issued2011-
dc.identifier.citationDevelopmental Dynamics, vol.240 no.4, pp. 850-861ko_KR
dc.identifier.issn1058-8388-
dc.identifier.urihttps://hdl.handle.net/10371/100302-
dc.description.abstractVesicular acidification at early endosomes dissociates endocytosed receptor-ligand complexes. The ligands, receptors, or both are then directed to late endosomes for degradation or recycled back to the plasma membrane. Of neuron-specific gene (NSG) family members, early endosomal protein neuron-specific gene family member 1 (NSG1) is the most important in receptor recycling. In this study, we characterized chicken NSG1 (cNSG1). We found several functional sites related to endocytotic machinery in cNSG1 that were highly conserved with most other vertebrate NSG1 proteins. We examined the tissue and duration specificity and the temporal and spatial patterns of cNSG1 expression. cNSG1 expression was preferentially located in all regions of the brain, neuroendocrine glands, and spinal cord. Unexpectedly, cNSG1 expression was strongly detected during male and female germ-line development. Expression of NSG1 in two apparently unrelated cell types such as neurons and germ cells suggests NSG1 roles in neurons and germ-cells chemotaxis and endocytotic machinery.ko_KR
dc.language.isoenko_KR
dc.publisherWileyko_KR
dc.subjectbrain-derived factorsko_KR
dc.subjectchickensko_KR
dc.subjectgerm-line developmentko_KR
dc.subjectneuron-specific gene family member 1 (NSG1)ko_KR
dc.titleThe Distribution of Neuron-Specific Gene Family Member 1 in Brain and Germ Cells: Implications for the Regulation of Germ-Line Development by Brainko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이보람-
dc.contributor.AlternativeAuthor박경제-
dc.contributor.AlternativeAuthor이상인-
dc.contributor.AlternativeAuthor강경수-
dc.contributor.AlternativeAuthor최진원-
dc.contributor.AlternativeAuthor강석진-
dc.contributor.AlternativeAuthor송권화-
dc.contributor.AlternativeAuthor한재용-
dc.identifier.doi10.1002/dvdy.22575-
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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