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Avian biomodels for use as pharmaceutical bioreactors and for studying human diseases

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Song, Gwonhwa; Han, Jae Yong
Issue Date
2011
Publisher
Wiley
Citation
Annals of the New York Academy of Sciences, vol.1229, pp. 69-75
Keywords
aviangerm cellstransgenesisbioreactorbiomodel
Abstract
Animal-based biotechnologies involve the use of domestic animals for the production of pharmaceuticals and various proteins in milk and eggs, as disease models, as tools for stem cell research and animal cloning, and as sources of organs for xenotransplantation into humans. Avian species offer several advantages over mammalian models, and they have been used historically to advance the fields of embryology, immunology, oncology, virology, and vaccine development. In addition, avian species can be used for studying the etiology of human ovarian cancer and other human diseases such as disorders based on the abnormal metabolism of lipids and as unique mechanisms for the biosynthesis and transport of cholesterol. This review integrates recent progress and insight into the molecular and physiologic mechanisms associated with transgenic birds and gives an overview of the use of avian models as pharmaceutical bioreactors and as tools for studying human diseases.
ISSN
0077-8923
Language
English
URI
https://hdl.handle.net/10371/100307
DOI
https://doi.org/10.1111/j.1749-6632.2011.06087.x
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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