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Matrix metalloproteinase 3 is a stromal marker for chicken ovarian cancer

Cited 20 time in Web of Science Cited 21 time in Scopus
Authors
Choi, Jin Won; Ahn, Suzie E.; Rengaraj, Deivendran; Seo, Hee Won; Lim, Whasun; Song, Gwonhwa; Han, Jae Yong
Issue Date
2011
Publisher
Spandidos Publications
Citation
Oncology Letters, vol.2 no.6, pp. 1047-1051
Keywords
chickenovaryovarian cancermatrix metallopro-teinases 3in situ hybridization
Abstract
Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix and basement membranes. Due to this, MMPs have been thought to promote invasion and metastasis of cancer cells and angiogenesis in tumors. Even though the chicken is a useful animal model for studying human ovarian cancer, no reports exist of the MMP expression pattern in chicken ovarian cancer. Therefore, we investigated the expression pattern of MMPs in chicken ovarian cancer. Results of RT-PCR and quantitative RT-PCR analyses showed MMP3 to be over\_expressed in cancerous hen ovaries. In situ hybridization analysis of cancerous chicken ovaries showed that MMP3 mRNA was predominantly localized in the stroma, which is similar to MMP3 expression in human cancers. The results suggest that the expression pattern of MMP3 mRNA in chicken ovarian cancer is similar to that in various types of human cancer. Moreover, MMP3 poten\-tially plays a significant role in developing ovarian cancer in chickens. The cell type\_ specific expression of MMP3 makes this gene a unique marker for ovarian cancer in chickens.
ISSN
1792-1074
Language
English
URI
https://hdl.handle.net/10371/100313
DOI
https://doi.org/10.3892/ol.2011.391
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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