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Chicken Pleiotrophin: Regulation of Tissue Specific Expression by Estrogen in the Oviduct and Distinct Expression Pattern in the Ovarian Carcinomas

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dc.contributor.authorLee, Jin-Young-
dc.contributor.authorJeong, Wooyoung-
dc.contributor.authorLim, Whasun-
dc.contributor.authorKim, Jinyoung-
dc.contributor.authorBazer, Fuller W.-
dc.contributor.authorHan, Jae Yong-
dc.contributor.authorSong, Gwonhwa-
dc.date.accessioned2017-02-01T02:11:19Z-
dc.date.available2017-02-01T02:11:19Z-
dc.date.issued2012-
dc.identifier.citationPLoS ONE, vol.7 no.4, e34215ko_KR
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10371/100332-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.
ko_KR
dc.description.abstractPleiotrophin (PTN) is a developmentally-regulated growth factor which is widely distributed in various tissues and also detected in many kinds of carcinomas. However, little is known about the PTN gene in chickens. In the present study, we found chicken PTN to be highly conserved with respect to mammalian PTN genes (91–92.6%) and its mRNA was most abundant in brain, heart and oviduct. This study focused on the PTN gene in the oviduct where it was detected in the glandular (GE) and luminal (LE) epithelial cells. Treatment of young chicks with diethylstilbesterol induced PTN mRNA and protein in GE and LE, but not in other cell types of the oviduct. Further, several microRNAs, specifically miR-499 and miR-1709 were discovered to influence PTN expression via its 39-UTR which suggests that post-transcriptional regulation influences PTN expression in chickens. We also compared expression patterns and CpG methylation status of the PTN gene in normal and cancerous ovaries from chickens. Our results indicated that PTN is most abundant in the GE of adenocarcinoma of cancerous, but not normal ovaries of hens. Bisulfite sequencing revealed that 30- and 40% of 21311 and 21339 CpG sites are demethylated in ovarian cancer cells, respectively. Collectively, these results indicate that chicken PTN is a novel estrogen-induced gene expressed mainly in the oviductal epithelia implicating PTN regulation of oviduct development and egg formation, and also suggest that PTN is a biomarker for epithelial ovarian carcinoma that could be used for diagnosis and monitoring effects of therapies for the disease.ko_KR
dc.language.isoenko_KR
dc.publisherPublic Library of Scienceko_KR
dc.titleChicken Pleiotrophin: Regulation of Tissue Specific Expression by Estrogen in the Oviduct and Distinct Expression Pattern in the Ovarian Carcinomasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이진영-
dc.contributor.AlternativeAuthor정우영-
dc.contributor.AlternativeAuthor임화선-
dc.contributor.AlternativeAuthor김진영-
dc.contributor.AlternativeAuthor한재용-
dc.contributor.AlternativeAuthor송권화-
dc.identifier.doi10.1371/journal.pone.0034215-
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