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Avian WNT4 in the Female Reproductive Tracts: Potential Role of Oviduct Development and Ovarian Carcinogenesis

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dc.contributor.authorLim, Chul-Hong-
dc.contributor.authorLim, Whasun-
dc.contributor.authorJeong, Wooyoung-
dc.contributor.authorLee, Jin-Young-
dc.contributor.authorBae, Seung-Min-
dc.contributor.authorKim, Jinyoung-
dc.contributor.authorHan, Jae Yong-
dc.contributor.authorBazer, Fuller W.-
dc.contributor.authorSong, Gwonhwa-
dc.date.accessioned2017-02-02T01:41:53Z-
dc.date.available2017-02-02T01:41:53Z-
dc.date.issued2013-
dc.identifier.citationPLoS ONE, vol.8 no.7, e65935ko_KR
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10371/100365-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.
ko_KR
dc.description.abstractThe wingless-type MMTV integration site family of proteins (WNTs) is highly conserved secreted lipid-modified signaling molecules that play a variety of pivotal roles in developmental events such as embryogenesis, tissue homeostasis and cell polarity. Although, of these proteins, WNT4 is known to be involved in genital development in fetuses of mammalian species, its role is unknown in avian species. Therefore, in this study, we investigated expression profiles, as well as hormonal and post-transcriptional regulation of WNT4 expression in the reproductive tract of female chickens. Results of this study demonstrated that WNT4 is most abundant in the stromal and luminal epithelial cells of the isthmus and shell gland of the oviduct, respectively. WNT4 is also most abundant in the glandular epithelium of the shell gland of the oviduct of laying hens at 3 h post-ovulation during the laying cycle. In addition, treatment of young chicks with diethylstilbestrol (DES, a synthetic estrogen agonist) stimulated WNT4 only in the glandular epithelial cells of the isthmus and shell gland of the oviduct. Moreover, results of our study demonstrated that miR-1786 influences WNT4 expression via specific binding sites in its 3′-UTR. On the other hand, our results also indicate that WNT4 is expressed predominantly in the glandular epithelium of cancerous ovaries, but not in normal ovaries of hens. Collectively, these results indicate cell-specific expression of WNT4 in the reproductive tract of chickens and that it likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens.ko_KR
dc.language.isoenko_KR
dc.publisherPublic Library of Scienceko_KR
dc.titleAvian WNT4 in the Female Reproductive Tracts: Potential Role of Oviduct Development and Ovarian Carcinogenesisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임철홍-
dc.contributor.AlternativeAuthor임화선-
dc.contributor.AlternativeAuthor정우영-
dc.contributor.AlternativeAuthor이진영-
dc.contributor.AlternativeAuthor배승민-
dc.contributor.AlternativeAuthor김진영-
dc.contributor.AlternativeAuthor한재용-
dc.contributor.AlternativeAuthor송권화-
dc.identifier.doi10.1371/journal.pone.0065935-
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