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Chicken NK-lysin is an alpha-helical cationic peptide that exerts its antibacterial activity through damage of bacterial cell membranes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mi Ok | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Han, Jae Yong | - |
dc.contributor.author | Womack, James E. | - |
dc.date.accessioned | 2017-02-02T02:12:56Z | - |
dc.date.available | 2017-02-02T02:12:56Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Poultry Science Journal, vol.93 no.4, pp. 864-870 | ko_KR |
dc.identifier.issn | 0032-5791 | - |
dc.identifier.uri | https://hdl.handle.net/10371/100376 | - |
dc.description.abstract | The antimicrobial peptides (AMP) are important elements of the first line of defense against pathogens in animals, and an important constituent of innate immunity. Antimicrobial peptides act on a broad spectrum of microbial organisms. NK-Lysin is a cationic antibacterial peptide that was originally isolated from porcine intestinal tissue based on its antibacterial activity. We synthesized peptides corresponding to each helical region of chicken NK-lysin and analyzed their secondary structures in addition to their antimicrobial activity. Circular dichroism spectroscopy of the synthetic chicken NK-lysin (cNK-78) and 4 small peptides in negatively charged liposomes demonstrated transition in the conformation of α-helical peptides relative to the charged environment. Chicken NK-lysin inhibits the growth of a representative gram-negative bacterium, Escherichia coli. The antimicrobial activity of 2 peptides designated H23 and H34 was similar to that of mature NK-lysin, cNK-78. Microscopic analyses revealed the death of bacterium with disrupted membranes after peptide treatment, suggesting that chicken NK-lysin, an alpha-helical cationic peptide, exerts its antimicrobial activity by damaging the bacterial cell membrane. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Oxford University Press | ko_KR |
dc.subject | NK-lysin | ko_KR |
dc.subject | antimicrobial peptide | ko_KR |
dc.subject | innate immunity | ko_KR |
dc.subject | chicken | ko_KR |
dc.title | Chicken NK-lysin is an alpha-helical cationic peptide that exerts its antibacterial activity through damage of bacterial cell membranes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이미옥 | - |
dc.contributor.AlternativeAuthor | 장현준 | - |
dc.contributor.AlternativeAuthor | 한재용 | - |
dc.identifier.doi | 10.3382/ps.2013-03670 | - |
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