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Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study

Cited 26 time in Web of Science Cited 25 time in Scopus
Authors
Kim, Soo Jung; Yoon, Soon Ho; Choi, Sun Mi; Lee, Jinwoo; Lee, Chang-Hoon; Han, Sung Koo; Yim, Jae-Joon
Issue Date
2017-01-05
Publisher
BioMed Central
Citation
BMC Pulmonary Medicine, 17(1):5
Keywords
Abdominal fatAnthropometryBody compositionNontuberculous mycobacteria
Description
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
Abstract
Abstract

Background
Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition.


Methods
Data from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6 months of follow up were included for analysis. NTM-LD progression was defined as clinician-initiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis.


Results
NTM-LD progressed in 47 out of 150 patients with more than 6 months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112–6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241–7.668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364–8.861), and serum albumin level <3.5 g/dL (aHR, 12.943; 95% CI, 2.588–64.718).


Conclusions
Progression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression.


Trial registration
ClinicalTrials.gov,
NCT01616745

Registered 25 March 2012
Language
English
URI
https://hdl.handle.net/10371/100449
DOI
https://doi.org/10.1186/s12890-016-0349-3
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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