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Contrast-enhanced MRI combined with MR cholangiopancreatography for the evaluation of patients with biliary strictures: differentiation of malignant from benign bile duct strictures

Cited 40 time in Web of Science Cited 49 time in Scopus
Authors
Kim, Ji Yang; Lee, Jeong Min; Han, Joon Koo; Kim, Se Hyung; Lee, Jae Young; Choi, Jin Young; Kim, Soo Jin; Kim, Hyuck Jung; Kim, Ki Hyeun; Choi, Byung Ihn
Issue Date
2007-07-12
Publisher
John Wiley & Sons
Citation
J Magn Reson Imaging 2007;26:304-312
Keywords
AdultAgedAged, 80 and overBile Duct Diseases/*diagnosis/pathologyBile Ducts/*pathologyBiliary Tract Diseases/*diagnosis/pathologyCholangiopancreatography, Magnetic Resonance/*methodsCholestasis/pathologyContrast Media/pharmacologyFemaleHumansLiver/metabolismMagnetic Resonance Imaging/*methodsMaleMiddle Aged
Abstract
PURPOSE: To determine imaging criteria for the combined use of contrast-enhanced (CE)-MRI and MR cholangiopancreatography (MRCP) to differentiate malignant from benign biliary strictures. MATERIALS AND METHODS: A total of 44 patients with biliary stricture who had undergone unenhanced, MRCP, and dynamic MRI were identified from radiological and surgical databases. Two radiologists analyzed MR features for asymmetry, luminal irregularity, abrupt narrowing, outer margin, signal intensity (SI) on T2-weighted (T2W) images, and hyperenhancement relative to liver parenchyma during portal phase. The wall thickness and length of the narrowed segment were measured. MR findings relevant as predictors were identified using a Chi-square or Fisher's exact test and the odds ratio (OR). RESULTS: The presence of hyperenhancement relative to liver parenchyma, length > 12 mm, wall thickness > 3 mm, indistinct outer margin, luminal irregularity, and asymmetry of strictured bile duct were significant factors for malignancy (P < 0.05). Malignant strictures were significantly thicker (5.0 +/- 2.0 mm) and longer (27.0 +/- 13.6 mm) than benign strictures. When any three or more of these six criteria were used in combination, we could identify 100% of malignant strictures and 87.0% of benign strictures. CONCLUSION: The combined use of CE-MRI and MRCP helped to define the criteria for differentiating malignant from benign biliary strictures in our data.
ISSN
1053-1807 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17623893

https://hdl.handle.net/10371/10446
DOI
https://doi.org/10.1002/jmri.20973
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Radiation Applied Life Science (대학원 협동과정 방사선응용생명과학전공)Journal Papers (저널논문_방사선응용생명과학전공)
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