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Reduced potency after refrigerated storage of botulitum toxin A: human extensor digitorum brevis muscle study

Cited 4 time in Web of Science Cited 6 time in Scopus
Authors
Paik, Nam-Jong; Seo, Kyle; Eun, Hee Chul
Issue Date
2006
Publisher
John Wiley & Sons
Citation
Mov Disord 2006;21:1759-1763
Keywords
botulinum toxinpotencystorageEreconstitution
Abstract
To determine whether the potency of botulinum toxin A (BTA) decreases after being reconstituted with normal saline and stored in refrigerator, we injected one side of the extensor digitorum brevis muscle with 2.5 units of botulinum toxin A that had been immediately reconstituted with saline, and the contralateral side with identical material that had been reconstituted and stored in a refrigerator for preselected periods (1, 2, and 4 weeks) in 32 healthy volunteers. Mean compound muscle action potential amplitudes expressed as a percentage of the baseline amplitude were more reduced in sides injected with immediately reconstituted BTA than in sides injected with BTA stored for 1 week or more (P < 0.05). No bacterial growth was observed in any stored BTA samples. Storage of reconstituted BTA at low temperatures may affect the potency of the toxin. Therefore, the use of BTA after refrigerated storage is not recommended.
ISSN
0885-3185 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16856132

https://hdl.handle.net/10371/11046
DOI
https://doi.org/10.1002/mds.21044
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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