Publications
Detailed Information
Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
Cited 83 time in
Web of Science
Cited 86 time in Scopus
- Authors
- Issue Date
- 2006
- Publisher
- Elsevier
- Citation
- Brain Res. 1073-1074, 190-201
- Keywords
- Granulocyte colony-stimulating ; factor (G-CSF) ; Neurogenesis ; G-CSFR ; STAT ; VEGF
- Abstract
- The adult brain harbors multipotent stem cells, which reside in specialized niches that support self-renewal. Granulocyte colony-stimulating factor (G-CSF) induces bone marrow stem cells proliferation and mobilization from their niche, and activates endothelial cell proliferation, which might help to establish a vascular niche for neural stem cells (NSCs). Here, we show that G-CSF induced receptor-mediated proliferation and differentiation of neural precursors in human NSCs cultures and in adult rat brain in vivo. In human NSCs cultures, G-CSF activated STAT3 and 5, and increased VEGF and its receptor, VEGFR2 (Flk-1) expression, and VEGFR2 tyrosine kinase inhibitor blocked the neurogenesis stimulated by G-CSF. G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation.
- ISSN
- 0006-8993 (Print)
- Language
- English
- URI
- http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4J2TSRB-9&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fc1cd00aeeb342a383d5fa2a1a7434a5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16423324
https://hdl.handle.net/10371/11093
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.