S-Space College of Medicine/School of Medicine (의과대학/대학원) Radiology (영상의학전공) Journal Papers (저널논문_영상의학전공)
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences
- Kim, J. H.; Chang, K. H.; Na, D. G.; Song, I. C.; Kwon, B. J.; Han, M. H.; Kim, K.
- Issue Date
- American Society of Neuroradiology
- AJNR Am J Neuroradiol 2006;27:1412-8
- Aspartic Acid/analogs & derivatives/analysis; Brain Neoplasms/*diagnosis; Choline/analysis; Creatine/analysis; Echo-Planar Imaging/methods; Glioma/*diagnosis; Hydrogen; Image Enhancement/methods; Inositol/analysis; Lactates/analysis; Lipids/analysis; Magnetic Resonance Spectroscopy/*methods; Phosphocreatine/analysis; Time Factors
- BACKGROUND AND PURPOSE: Echo time (TE) can have a large influence on the spectra in proton MR spectroscopy ((1)H-MR spectroscopy). The purpose of this study was to comparatively assess the diagnostic value of 3T single-voxel (1)H-MR spectroscopy with short or intermediate TEs in grading cerebral gliomas. METHODS: Single voxel (1)H-MR spectroscopy was performed at 3T in 35 patients with cerebral glioma. The spectra were obtained with both short (35 ms) and intermediate TEs (144 ms). Metabolite ratios of choline (Cho)/creatine (Cr), Cho/N-acetylaspartate (NAA), lipid and lactate (LL)/Cr and myo-inositol (mIns)/Cr were calculated and compared between short and intermediate TEs in each grade. After receiver operating characteristic curve analysis, diagnostic accuracy for each TE in differentiating high-grade glioma from low-grade glioma was compared. RESULTS: At short TE, Cho/Cr and Cho/NAA ratios were significantly lower, and LL/Cr and mIns/Cr were significantly higher, compared with those at intermediate TE, regardless of tumor grade. Lactate inversion at intermediate TE was found in only 2 patients. At both TEs, there were significant differences in Cho/Cr and LL/Cr ratios between low- and high-grade gliomas. Diagnostic accuracy was slightly higher at short TE alone or combined with intermediate TE than intermediate TE alone (85.7% versus 82.9%). CONCLUSION: Metabolite ratios were significantly different between short and intermediate TE. Cho/Cr and LL/Cr ratios at either TE were similarly useful in differentiating high-grade gliomas from low-grade gliomas. If only a single spectroscopic sequence can be acquired, short TE seems preferable because of poor lactate inversion at intermediate TE on 3T single-voxel (1)H-MR spectroscopy.
- 0195-6108 (Print)
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