S-Space College of Medicine/School of Medicine (의과대학/대학원) Laboratory Medicine (검사의학전공) Journal Papers (저널논문_검사의학전공)
Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies
- Kim, Inho; Yoon, Sung Soo; Lee, Kyung-Hun; Keam, Bhumsuk; Kim, Tae Min; Kim, Jin-Soo; Kim, Hoon-Gu; Oh, Myoung-Don; Han, Kyou-Sup; Park, Myoung Hee; Park, Seonyang; Kim, Byoung Kook
- Issue Date
- Blackwell Publishing
- Clin Transplant. 2006 Jul-Aug;20(4):496-503.
- Adult; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Female; Graft vs Host Disease; Hematologic Neoplasms/mortality/*therapy; Hematopoietic Stem Cell Transplantation/*methods; Histocompatibility Testing; Humans; Male; Melphalan/administration & dosage; Middle Aged; Survival Analysis; Transplantation Conditioning; Transplantation, Homologous/*physiology; Treatment Outcome
- We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies<50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)-matched donors, via either reduced intensity (n=35) or myeloablative conditioning (n=70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p=0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count>0.5x10(9)/L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0-21 d) than in the myeloablative group (median: 18 d; range: 11-38 d; p<0.0001). The incidence of grades 2-4 acute graft-vs.-host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p=0.40). The cumulative incidence of day 100 non-relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p=0.88). The overall two-yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p=0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies.
- 0902-0063 (Print)
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