S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Ph.D. / Sc.D._의학과)
Efficacy of A Mouse Anti-human ICAM-1 Monoclonal Antibody, MD-3, for Kidney Transplantation in Rhesus Monkeys
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과 외과학전공, 2016. 2. 하종원.
- Introduction: The MD-3 is a newly developed chimeric anti-human intracellular adhesion molecule 1 (ICAM-1) monoclonal antibody (mAb). The effects of this monoclonal antibody in solid organ transplantation have not been elucidated.
Methods: Five rhesus monkey renal allograft recipients treated with MD-3 induction and one recipient without MD-3 treatment were studied for the incidence of acute rejection and donor-specific antibody development. Cellular immune response was tested with ELISPOT assay. Development of anti-drug antibody was also tested. Maintenance immunosuppression included anti-CD154 mAb (hu5C8), mycophenolate mofetil and corticosteroid.
Results: No recipient monkey developed acute rejection as long as 8 months after transplantation. Donor-specific antibody was not developed in monkeys treated with MD-3. A monkey without MD-3 induction started to produce donor-specific antibody 3 weeks after cessation of anti-CD154mAb and persisted. No anti-drug antibody was detected during the study period.
Conclusions: MD-3 can be a highly promising agent for clinical use in human allotransplantation and MD-3 treatment can allow optimization of kidney transplant outcome. Further studies for refining dosages and dosing schedule of MD-3 in kidney transplantation are required.