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The Protective Effect of Systemic Steroid Administration in Hearing Preservation after Cochlear Implantation in Guinea Pigs : 기니픽 동물 모델에서 전신적 스테로이드 투여의 와우 이식 후 청력 보존 효과에 대한 고찰
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이준호 | - |
dc.contributor.author | 나윤찬 | - |
dc.date.accessioned | 2017-07-14T01:39:44Z | - |
dc.date.available | 2017-07-14T01:39:44Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.other | 000000141554 | - |
dc.identifier.uri | https://hdl.handle.net/10371/122218 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2017. 2. 이준호. | - |
dc.description.abstract | Objectives: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after cochlear implantation (CI).
Methods: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. The control group underwent CI without steroid infusion. A dummy CI electrode was inserted via a cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out. Results: No differences were found in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less loose connective tissue deposition, less dense fibrosis in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group. Conclusion: Seven-day administration of systemic steroids was more effective in preserving residual hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery. | - |
dc.description.tableofcontents | Introduction 1
Material and Methods 3 Experimental animals and group allocation 3 Steroid infusion and cochlear implantation 4 Auditory threshold measurement 5 Histology 6 Statistical analysis 7 Results 9 Hearing changes 9 Histologic changes 10 Discussion 14 Conclusion 19 References 20 국문초록 39 | - |
dc.format | application/pdf | - |
dc.format.extent | 1126094 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Cochlear implant | - |
dc.subject | Hearing loss | - |
dc.subject | Steroid | - |
dc.subject.ddc | 610 | - |
dc.title | The Protective Effect of Systemic Steroid Administration in Hearing Preservation after Cochlear Implantation in Guinea Pigs | - |
dc.title.alternative | 기니픽 동물 모델에서 전신적 스테로이드 투여의 와우 이식 후 청력 보존 효과에 대한 고찰 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Yoon Chan Rah | - |
dc.description.degree | Doctor | - |
dc.citation.pages | iv, 40 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2017-02 | - |
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