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Studies on characteristics of CD8 T cell response for minor histocompatibility antigen, H60 and role of myeloid cells in the development of t cell response
부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구

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Authors
류수정
Advisor
최은영
Major
의과대학 의과학과
Issue Date
2016-02
Publisher
서울대학교 대학원
Keywords
minor histocompatibility antigenH60immune tolerance
Description
학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과 의과학전공, 2016. 2. 최은영.
Abstract
The balance between immunity and tolerance is required to maintain immune homeostasis. Understanding how tolerance can be induced extrathymically has important implication for attempts to establish a nonresponsive state to allogeneic antigens borne on tissue grafts and for reestablishing self-tolerance in patients suffering from autoimmune disease. In this study, I investigated whether the induction of help-deficient CD8 T cell response for H60 could generate memory impairment of the H60-specific CD8 T cells and whether the memory impairment of CD8 T cell specific for H60, the most dominant minor H antigen, would influence the immune hierarchy of CD8 T cells specific for other minor H antigens. Helper-deficient CD8 T cells show reduced burst expansion and the tolerance of H60-specific CD8 T cells has rendered CD8 T cells specific for other minor H antigens to be tolerized as well, reducing the total intensity of allo-response induced after transplantation.
To understand the thymic selection process for H60-specific CD8 T cells and control of the specific response, I investigated the effect of a single amino acid substitution in the H60 epitope on the composition of the TCR repertoire. These results demonstrated that some overlap in TCR usage between CD8 T cells responding to H60H vs. H60N stimulation, suggesting that the H60H epitope will be useful for understanding the selection process and control of CD8 T cells specific for H60.
In the third part, I showed that differentiation of transplanted Lin- cells into myeloid-derived suppressor cells inflamed skin to be the basis of the alleviation of skin inflammation after Lin- cell transplantation. Taken together, these results provide insight for modeling therapeutic applications to control CD8 T cell response.
Language
English
URI
https://hdl.handle.net/10371/122301
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Theses (Ph.D. / Sc.D._의과학과)
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