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Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes
금/은 빈 공간 나노쉘의 폐암 세포 표면 축적을 이용한 특정 세포 탐지 기능성 근적외선 유도약물 방출 및 광열 치료 효과

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Authors
노미숙
Advisor
조명행
Major
융합과학기술대학원 융합과학부(나노융합전공)
Issue Date
2015-08
Publisher
서울대학교 융합과학기술대학원
Keywords
hollow-shellsphotothermal therapytargeted drug deliverytriggered releaselung cancerdoxorubicinEGFR
Description
학위논문 (박사)-- 서울대학교 융합과학기술대학원 : 융합과학부 나노융합전공, 2015. 8. 조명행.
Abstract
Au/Ag hollow nanoshells (AuHNSs) were developed as multifunctional therapeutic agents for effective, targeted, photothermally induced drug delivery under near-infrared (NIR) light. AuHNSs were synthesized by galvanic replacement reaction. We further conjugated antibodies against the epidermal growth factor receptor (EGFR) to the PEGylated AuHNS, followed by loading with the antitumor drug doxorubicin (AuHNS-EGFR-DOX) for lung cancer treatment. AuHNSs showed similar photothermal efficiency to gold nanorods under optimized NIR laser power. The targeting of AuHNS-EGFR-DOX was confirmed by light-scattering images of A549 cells, and doxorubicin release from the AuHNSs was evaluated under low pH and NIR-irradiated conditions. Multifunctional AuHNS-EGFR-DOX induced photothermal ablation of the targeted lung cancer cells and rapid doxorubicin release following irradiation with a NIR laser. Furthermore, we evaluated the effectiveness of AuHNS-EGFR-DOX drug delivery by comparing two drug delivery methods: receptor-mediated endocytosis and cell-surface targeting. Accumulation of the NPs on the cell surfaces by targeting EGFR demonstrated more effective for lung cancer treatments than uptake of AuHNS-EGFR-DOX. Taken together, our data suggest a new and optimal method of NIR-induced drug release, via the accumulation of targeted AuHNS-EGFR-DOX on cancer cell membranes.
Language
English
URI
http://hdl.handle.net/10371/122378
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Transdisciplinary Studies(융합과학부)Theses (Ph.D. / Sc.D._융합과학부)
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